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Section 4.1
Genetics and Immunology of Blood Groups
Why do IgM antibodies, such as those formed against the ABO antigens, have the ability to directly agglutinate red blood cells (RBCs) and cause visible agglutination?
IgM antibodies are larger molecules and have the ability to bind more antigen
IgM antibodies tend to clump together more readily to bind more antigen
IgM antibodies are found in greater concentrations than IgG antibodies
IgM antibodies are not limited by subclass specificity
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